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Description: TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM. Target: TRP/TRPV Channel. Smiles: Fc1ccc(NC(=O)N2CCc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1. References: Tamayo N A , Bo Y , Gore V , et al. Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists[J]. Journal of Medicinal Chemistry, 2012, 55(4):1593-1611.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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