59 products were found matching "K04983"!

Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat), TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent...

AMG 2850 is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits menthol- or cold-induced intracellular calcium release in CHO cells expressing rat TRPM8 (IC50s = 7. and 150 nM, respectively). AMG 2850 is selective for TRPM8 over transient receptor potential ankyrin 1 (TRPA1), transient...

RQ-00203078 is a selective antagonist of transient receptor potential melastatin 8 (TRPM8, IC50s = 8.3 and 5.8 nM in human and rat, respectively), while having little inhibitory action against TRPV1 (IC50 > 30 µM), TRPA1 (IC50 > 10 µM), TRPV4 (IC50 = 10 µM), or TRPM2 channels (IC50 > 10 µM). It attenuates...

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Cay-10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no...

Description: PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain. Target: TRP/TRPV Channel. Smiles: C[C@@H](N(Cc1cccc(c1)C(O)=O)C(=O)c1cnc2ccccc2c1)c1ccc(F)cc1. References: Andrews MD, et al. Discovery of a Selective TRPM8 Antagonist with Clinical...

Description: WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM). Target: TRP/TRPV Channel. Smiles: C(NC1=CC=C(OC)C=C1)(=O)[C@H]2[C@H]([C@H](C)C)CC[C@@H](C)C2. References: Beck B , Bidaux G , Bavencoffe A , et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8...

Description: ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. Target: TRP/TRPV Channel. Smiles: Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O. References: Lee S, et al. Biochem Biophys Res Commun. 2013 Nov 29,441(4):1005-10.

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Transient receptor potential cation channel subfamily M member 8, also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. TRPM8 is an ion channel, upon activation it allows the entry of Na+ (sodium) and...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol...

In 1X PBS, pH 7.4, with 0.09% sodium azide. TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and...

In 1X PBS, pH 7.4, with 0.09% sodium azide. TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and...

In 1X PBS, pH 7.4, with 0.09% sodium azide. TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and...