TC 13172
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An inhibitor of MLKL and necroptosis, selective for MLKL over RIPK1 and RIPK3 at 10 µM, inhibits... more
Product information "TC 13172"
An inhibitor of MLKL and necroptosis, selective for MLKL over RIPK1 and RIPK3 at 10 µM, inhibits TSZ-induced necroptosis in HT-29 cells (EC50 = 2 nM), inhibits TSZ-induced oligomerization of MLKL and translocation of MLKL to the plasma membrane in HT-29 cells at 100 nM. Formulation: A solid. InChI: InChI=1S/C17H16N4O5S/c1-19-13-14(18-16(19)27(3,25)26)21(17(24)20(2)15(13)23)9-5-7-11-6-4-8-12(22)10-11/h4,6,8,10,22H,9H2,1-3H3. InChIKey: ZTQLCNOQWGSELY-UHFFFAOYSA-N. SMILES: O=C1C2=C(N(C(N1C)=O)CC#CC3=CC=CC(O)=C3)N=C(N2C)S(C)(=O)=O
| Keywords: | 3,7-dihydro-3-[3-(3-hydroxyphenyl)-2-propyn-1-yl]-1,7-dimethyl-8-(methylsulfonyl)-1H-purine-2,6-dione |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 31034 |
Properties
| Application: | MLKL / necroptosis inhibitor |
| MW: | 388.4 D |
| Formula: | C17H16N4O5S |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2093393-05-4| Matching products |
| KEGG ID : | K08849 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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