TBPB

TBPB is an allosteric agonist of M1 muscarinic acetylcholine receptors (mAChRs, EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors). It is selective for M1 over M2-5 receptors at concentrations up to 10 µM. TBPB (3 µM) potentiates NMDA-evoked currents in CA1 pyramidal cells. It increases production of the non-amyloidogenic amyloid precursor protein (APP) cleavage products APPsalpha and CTFalpha in PC12 cells overexpressing the human M1 receptor and APP when used at a concentration of 1 µM. TBPB decreases amphetamine-induced hyperlocomotion in a rat model that is predictive of antipsychotic-like activity.Formal Name: 1,3-dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one. CAS Number: 634616-95-8. Molecular Formula: C25H32N4O. Formula Weight: 404.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 30 mg/ml, DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC(C=CC=C1)=C1CN(CC2)CCC2N3CCC(N4C(NC5=C4C=CC=C5)=O)CC3. InChi Code: InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30). InChi Key: CWPKTBMRVATCBL-UHFFFAOYSA-N.