TB 21007

TB 21007 is an inverse agonist of alpha5beta3gamma2 subunit-containing GABAA receptors (Ki = 1.6 nM). It selectively inhibits alpha5beta3gamma2 subunit-containing GABAA receptors over alpha1-4 and alpha6 subunit-containing GABAA receptors that also contain beta3 and gamma2 subunits (Kis = 20, 16, 20, 106, and 1,800 nM, respectively). TB 21007 reduces the latency to find the hidden platform in a matching-to-place variant of the Morris water maze, indicating enhanced spatial memory, in rats when administered at a dose of 0.3 mg/kg. It reduces paw tactile allodynia induced by reserpine (Cay-16474) in a rat model of fibromyalgia-like pain when administered intrathecally at doses of 1.5, 15, and 150 nmol.Formal Name: 6,7-dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one. CAS Number: 207306-50-1. Molecular Formula: C15H17NO2S3. Formula Weight: 339.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 25 mM. SMILES: O=C1C2=C(SCCO)SC(C3=NC=CS3)=C2CC(C)(C)C1. InChi Code: InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3. InChi Key: QILRYFCEXLFIDS-UHFFFAOYSA-N.