TAS 102

TAS 102 is an orally bioavailable combination of the antimetabolite nucleoside analog trifluorothymidine (TFT, Cay-21366) with the thymidine phosphorylase (TPase) inhibitor tipiracil (TPI, Cay-23319). In vivo, TAS 102 inhibits tumor growth by 65.7 and 44.9% in HCT116 and KM12C colon cancer xenograft mouse models, respectively, when administered at a dose of 150 mg/kg per day for 14 days.Formal Name: alpha,alpha,alpha-trifluoro-thymidine mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione, monohydrochloride. CAS Number: 2300074-31-9. Molecular Formula: C10H11F3N2O5 . 1/2C9H11ClN4O2 . 1/2HCl. Formula Weight: 435.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. lambdamax: 263 nm. SMILES: O=C(NC(C(C(F)(F)F)=C1)=O)N1[C@H]2C[C@H](O)[C@@H](CO)O2.O=C(NC(C(C(F)(F)F)=C3)=O)N3[C@H]4C[C@H](O)[C@@H](CO)O4.ClC5=C(CN6CCCC6=N)NC(NC5=O)=O.Cl. InChi Code: InChI=1S/2C10H11F3N2O5.C9H11ClN4O2.ClH/c2*11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7,10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11,/h2*2,5-7,16-17H,1,3H2,(H,14,18,19),11H,1-4H2,(H2,12,13,15,16),1H/t2*5-,6+,7+,,/m00../s1. InChi Key: KTHXRTQHERFOMN-GIZOTSQLSA-N.