Taminadenant

An adenosine A2A receptor antagonist (Ki = 12 nM), selective for adenosine A2A receptors over adenosine A1-, A2B-, and A3 receptors (Kis = 2,500, 1,000, and 5,000 nM, respectively), increases the levels of IFN-gamma secreted by tumor-associated T cells isolated from patient-derived lung tumors at 1 µM when used in combination with an antibody targeting PD-1 or PD-L1, reduces the number of lung nodules in an MCA-205 murine fibrosarcoma model of lung metastasis at 15 mg/kg per day, inhibits haloperidol-induced catalepsy in a rat model of Parkinson's disease motor symptoms at 3, 10, or 30 mg/kg. Formulation: A solid. InChI: InChI=1S/C10H8BrN7/c11-7-8(12)15-10(18-6-2-4-14-18)16-9(7)17-5-1-3-13-17/h1-6H,(H2,12,15,16). InChIKey: ATFXVNUWQOXRRU-UHFFFAOYSA-N. SMILES: NC1=C(Br)C(N2N=CC=C2)=NC(N3N=CC=C3)=N1