Sumatriptan-d6 (succinate)

Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan (Cay-14600) by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively). It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 (Cay-29651). Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans. Formulations containing sumatriptan have been used in the treatment of migraine headache.Formal Name: 3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1). CAS Number: 1397195-80-0. Molecular Formula: C14H15D6N3O2S . 1/2C4H6O4. Formula Weight: 360.4. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(CCC(O)=O)O.CNS(CC1=CC=C(NC=C2CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C2=C1)(=O)=O.CNS(CC3=CC=C(NC=C4CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C4=C3)(=O)=O. InChi Code: InChI=1S/2C14H21N3O2S.C4H6O4/c2*1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3,5-3(6)1-2-4(7)8/h2*4-5,8-9,15-16H,6-7,10H2,1-3H3,1-2H2,(H,5,6)(H,7,8)/i2*2D3,3D3,. InChi Key: HIMZTGQXEPNRFN-LXRVQIONSA-N.