Sulfamethoxypyridazine

Sulfamethoxypyridazine is a sulfonamide antibiotic that inhibits the growth of Gram-negative bacteria and other microorganisms. It inhibits recombinant P. carinii dihydropteroate synthase (DHPS, IC50 = 17 nM) and folate biosynthesis in P. carinii by 75% when used at a concentration of 50 nM. Sulfamethoxypyridazine (0.25 mg/ml) inhibits any visible growth in culture tubes of 378 out of 530 E. coli isolates from necropsied animals and poultry. It also decreases the number of viable amoxicillin-induced B. burgdorferi round body forms to 30% of control when used at a concentration of 50 µM. In vivo, sulfamethoxypyridazine decreases the number of P. carinii trophozoite and cyst lesions in lung tissue in a mouse model of pneumonia infection (ED50s = 0.06 and 0.08 mg/kg per day, respectively).Formal Name: 4-amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide. CAS Number: 80-35-3. Molecular Formula: C11H12N4O3S. Formula Weight: 280.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 269 nm. SMILES: NC1=CC=C(S(NC2=CC=C(OC)N=N2)(=O)=O)C=C1. InChi Code: InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15). InChi Key: VLYWMPOKSSWJAL-UHFFFAOYSA-N.