Sulfadoxin-d4

Sulfadoxin-d4 is intended for use as an internal standard for the quantification of sulfadoxin (Cay-21488) by GC- or LC-MS. Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Cay-20515) synthesis. Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid. Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum. Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).Formal Name: 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamide-d4. CAS Number: 1330266-05-1. Synonyms: Ro 4-4393-d4. Molecular Formula: C12H10D4N4O4S. Formula Weight: 314.4. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, DMSO: soluble, Methanol: soluble. SMILES: O=S(NC1=NC=NC(OC)=C1OC)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])N)=O. InChi Code: InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)/i3D,4D,5D,6D. InChi Key: PJSFRIWCGOHTNF-LNFUJOGGSA-N.