Suc-YVAD-AMC (acetate)

Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name: (3S,6S,9S,12S)-12-(4-hydroxybenzyl)-9-isopropyl-6-methyl-3-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaheptadecanedioic acid, acetate. Synonyms: Suc-Tyr-Val-Ala-Asp-AMC, Suc-Tyr-Val-Ala-Asp-7-amino-4-methylcoumarin, Suc-YVAD-NH-Mec. Molecular Formula: C35H41N5O12 . XC2H4O2. Formula Weight: 723.7. Purity: >95%. Emission: 360, 460 nm. Excitation: 340, 440 nm. Formulation: (Request formulation change), A solid. Solubility: Formic Acid: 1 mg/ml. SMILES: O=C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(CCC(O)=O)=O)=O)=O)N[C@H](C(NC2=CC=C3C(C)=CC(OC3=C2)=O)=O)CC(O)=O.CC(O)=O. InChi Code: InChI=1S/C35H41N5O12.C2H4O2/c1-17(2)31(40-34(50)24(38-27(42)11-12-28(43)44)14-20-5-8-22(41)9-6-20)35(51)36-19(4)32(48)39-25(16-29(45)46)33(49)37-21-7-10-23-18(3)13-30(47)52-26(23)15-21,1-2(3)4/h5-10,13,15,17,19,24-25,31,41H,11-12,14,16H2,1-4H3,(H,36,51)(H,37,49)(H,38,42)(H,39,48)(H,40,50)(H,43,44)(H,45,46),1H3,(H,3,4)/t19-,24-,25-,31-,/m0./s1. InChi Key: RASLRTJPATXDHE-KDAALZGHSA-N.