SU 6668

SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors. It also inhibits metastasis in a mouse orthotopic model of melanoma. SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases.Formal Name: 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid. CAS Number: 252916-29-3. Synonyms: NSC 702827, Orantinib, TSU-68. Molecular Formula: C18H18N2O3. Formula Weight: 310.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml, DMSO: 2.5 mg/ml. lambdamax: 212, 279, 447 nm. SMILES: O=C1NC2=CC=CC=C2/C1=C/C3=C(C)C(CCC(O)=O)=C(C)N3. InChi Code: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9-. InChi Key: NHFDRBXTEDBWCZ-ZROIWOOFSA-N.