245 products were found matching "K05089"!
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PDGFRbeta Inhibition Reporter Assay System (human)
Item number: IB-IB23201
Protein Function: Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an...
| Keywords: | PDGFRB, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor... |
| Application: | Functional activity screening |
| Species reactivity: | human |
From 1,588.00€
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Anti-Recombinant PDGFR-beta, clone 4B12
Item number: E-AN300813L.100
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Keywords: | Anti-PDGFRB, Anti-CD140 antigen-like family member B, Anti-Platelet-derived growth factor receptor 1, Anti-Beta... |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 257.00€
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Sorafenib
Item number: LKT-S5868.100
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
| Keywords: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
| Application: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
From 109.00€
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JNJ-10198409
Item number: Cay10008131-1
Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity. JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value...
| Keywords: | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
| Application: | PDGF-BB inhibitor |
| CAS | 627518-40-5 |
| MW: | 325.3 D |
From 44.00€
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CP 673,451
Item number: Cay19170-1
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor beta (PDGFRbeta) kinase with an IC50 value of 1 nM. It also inhibits the PDGFRalpha kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2. In several in...
| Keywords: | 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Application: | PDGFRbeta inhibitor |
| CAS | 343787-29-1 |
| MW: | 417.5 D |
From 69.00€
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SU 6668
Item number: Cay13873-1
SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of...
| Keywords: | NSC 702827, Orantinib, TSU-68, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Application: | Tyrosine kinase inhibitor |
| CAS | 252916-29-3 |
| MW: | 310.4 D |
From 49.00€
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Crenolanib
Item number: Cay18873-5
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor alpha (PDGFRalpha) and PDGFRbeta and Fms-related tyrosine kinase 3 (FLT3, IC50s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant...
| Keywords: | CP 868,596, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Application: | PDGFR tyrosine kinase inhibitor |
| CAS | 670220-88-9 |
| MW: | 443.5 D |
From 73.00€
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Dasatinib
Item number: TGM-T1448-50mg
Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
| Keywords: | BMS-354825 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 302962-49-8 |
| MW: | 488.01 D |
From 36.00€
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AG-370
Item number: Cay10010568-5
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF)...
| Keywords: | NSC 651712, 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile |
| Application: | PDGF receptor kinase inhibitor |
| CAS | 134036-53-6 |
| MW: | 259.3 D |
From 89.00€
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AG-1295
Item number: Cay14529-1
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the...
| Keywords: | NSC 380341, Tyrphostin AG-1295, 6,7-dimethyl-2-phenyl-quinoxaline |
| Application: | PDGF receptor kinase inhibitor |
| CAS | 71897-07-9 |
| MW: | 234.3 D |
From 51.00€
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Anti-PDGFR-beta
Item number: E-AB-32531.20
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a...
| Keywords: | Anti-PDGFR, Anti-PDGFRB, Anti-CD140b, Anti-PDGFR-1, Anti-PDGFR-beta, EC=2.7.10.1, Anti-PDGF-R-beta, Anti-CD140... |
| Application: | WB, IHC (paraffin), IF, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 89.00€
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Imatinib free base
Item number: LKT-I4800.25
Inhibitor of Abl, c-Kit, and PDGFR.
| Application: | Bcr-Abl / PDGFRA / PDGFRB / c-KIT tyrosine kinase inhibitor |
| CAS | 152459-95-5 |
| MW: | 493.62 D |
From 87.00€
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