SU 0268

SU 0268 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1, IC50 = 0.059 µM). It is selective for OGG1 over the DNA repair enzymes MTH1, dUTPase, NUDT16, ABH2, ABH3, and SMUG1 at 20 µM. SU 0268 (0.5 µM) inhibits OGG1 and increases the number of 8-oxoguanine DNA lesions in HeLa cell lysates.Formal Name: 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-[1,1'-biphenyl]-3-carboxamide. CAS Number: 2210228-45-6. Molecular Formula: C26H25N3O4S. Formula Weight: 475.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): insol. lambdamax: 254 nm. SMILES: O=C(C1=CC(C2=CC=C(S(=O)(NC3=CC=C4C(N(CCC4)C(C5CC5)=O)=C3)=O)C=C2)=CC=C1)N. InChi Code: InChI=1S/C26H25N3O4S/c27-25(30)21-4-1-3-20(15-21)17-9-12-23(13-10-17)34(32,33)28-22-11-8-18-5-2-14-29(24(18)16-22)26(31)19-6-7-19/h1,3-4,8-13,15-16,19,28H,2,5-7,14H2,(H2,27,30). InChi Key: XGGNCZLDTJOSFV-UHFFFAOYSA-N.