Stiripentol

Stiripentol is a third-generation antiepileptic compound. It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing alpha3 subunits and to a lower extent in those containing beta1 or epsilon subunits. It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices. Stiripentol (500 µM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5. Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.Formal Name: 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol. CAS Number: 49763-96-4. Synonyms: BCX 2600. Molecular Formula: C14H18O3. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 30 mg/m, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 263, 306 nm. SMILES: OC(C(C)(C)C)/C=C/C1=CC(OCO2)=C2C=C1. InChi Code: InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+. InChi Key: IBLNKMRFIPWSOY-FNORWQNLSA-N.