ST 91

ST 91 is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It induces cAMP accumulation in HEK293 cells expressing alpha2A-, alpha2B-, or alpha2C-ARs (EC50s = 155, 371, and 851 nM, respectively). ST 91 (100 nM) inhibits isoproterenol-induced relaxation in phenylephrine-precontracted isolated rat mesenteric arterial rings. Intrathecal administration of ST 91 (10 and 30 µg/animal) reduces paw flinching in the first and second phases of the formalin test in rats. It increases plasma atrial natriuretic peptide (ANP) levels, urinary output, and sodium, potassium, and cGMP excretion in conscious rats when administered at a dose of 250 µg/animal. InChI: InChI=1S/C13H19N3.ClH/c1-3-10-6-5-7-11(4-2)12(10)16-13-14-8-9-15-13,/h5-7H,3-4,8-9H2,1-2H3,(H2,14,15,16),1H InChIKey: ZLRWFGBEDNTMEU-UHFFFAOYSA-N SMILES: CCC1=C(C(CC)=CC=C1)NC2=NCCN2.Cl