SRI-37330

SRI-37330 is an inhibitor of thioredoxin-interacting protein (TXNIP). It inhibits the expression of Txnip mRNA in INS-1 rat insulinoma cells (IC50 = 0.64 µM) and decreases Txnip protein levels in the same cells in a concentration-dependent manner. SRI-37330 (10 µM) inhibits LPS-induced pyroptosis in A549 cells overexpressing fat mass and obesity-associated (FTO) protein in an in vitro model of acute lung injury. In vivo, SRI-37330 (100 mg/kg) reduces non-fasting and fasting blood glucose levels, serum glucagon levels, and hepatic glucose production in wild-type and db/db mice. It also decreases non-fasting blood glucose levels, urinary glucose levels, and serum triglyceride levels in a mouse model of diabetes induced by streptozotocin (STZ, Cay-13104).Formal Name: N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]-methanesulfonamide. CAS Number: 2322245-42-9. Molecular Formula: C16H19F3N4O2S. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Water: Slightly soluble. SMILES: FC(F)(F)C1=CC=C(N=CN=C2N3CC(CNS(C)(=O)=O)CCC3)C2=C1. InChi Code: InChI=1S/C16H19F3N4O2S/c1-26(24,25)22-8-11-3-2-6-23(9-11)15-13-7-12(16(17,18)19)4-5-14(13)20-10-21-15/h4-5,7,10-11,22H,2-3,6,8-9H2,1H3. InChi Key: WRSNFEVXRKOMLL-UHFFFAOYSA-N.