SR 16832

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It inhibits MRL20-induced allosteric activation of PPARgamma in a reporter assay using HEK293T cells when used at a concentration of 5 µM. SR 16832 also reduces basal activity of PPARgamma and inhibits binding of docosahexaenoic acid (DHA, Cay-90310) to PPARgamma in a time-resolved FRET (TR-FRET) assay.Formal Name: 2-chloro-N-(6-methoxy-4-quinolinyl)-5-nitro-benzamide. CAS Number: 2088135-12-8. Molecular Formula: C17H12ClN3O4. Formula Weight: 357.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 233 nm. SMILES: COC1=CC=C2C(C(NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)=CC=N2)=C1. InChi Code: InChI=1S/C17H12ClN3O4/c1-25-11-3-5-15-13(9-11)16(6-7-19-15)20-17(22)12-8-10(21(23)24)2-4-14(12)18/h2-9H,1H3,(H,19,20,22). InChi Key: CVTZAGCRUDYUGB-UHFFFAOYSA-N.