Sodium dichloroacetate
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Larger quantity required? Request bulk
Description: Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase... more
Product information "Sodium dichloroacetate"
Description: Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 µM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth. Target: Dehydrogenase, Apoptosis, Reactive Oxygen Species, PDK. Smiles: C(C(=O)[O-])(Cl)Cl.[Na+]. References: Bonnet S, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007 Jan,11(1):37-51.
| Keywords: | Sodium Dichloroacetate, BCA, bichloroacetic acid, DCA, Sodium dichloroacetate (DCA) |
| Supplier: | TargetMol |
| Supplier-Nr: | T3604 |
Properties
| Application: | Targets pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2] (PDK2_3_4) |
| MW: | 150.92 D |
| Formula: | C2HCl2NaO2 |
Database Information
| CAS : | 2156-56-1| Matching products |
| KEGG ID : | K00898 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335, H351 |
| P Phrases: | P201, P202, P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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