SMER28

SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. SMER28 induces clearance of amyloid-beta (Abeta) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/-), mouse embryos in a concentration-dependent manner. It induces autophagy independently of rapamycin (Cay-13346) in mammalian cells at a concentration of 47 µM. SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.Formal Name: 6-bromo-N-2-propen-1-yl-4-quinazolinamine. CAS Number: 307538-42-7. Molecular Formula: C11H10BrN3. Formula Weight: 264.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL. lambdamax: 213, 296, 325, 339 nm. SMILES: BrC1=CC(C(NCC=C)=NC=N2)=C2C=C1. InChi Code: InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15). InChi Key: BCPOLXUSCUFDGE-UHFFFAOYSA-N.