SirReal1-O-propargyl

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T18641-100mg	100 mg				7 - 10 business days*		-
TGM-T18641-500mg	500 mg				7 - 10 business days*		-

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Description: SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent... more

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Product information "SirReal1-O-propargyl"

Description: SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 µM. It operates by binding to the cereblon ligand through a linker, facilitating the formation of PROTAC for the degradation of Sirt2[1]. Target: Others. Smiles: O=C(NC1=NC=C(S1)CC=2C=CC=C(OCC#C)C2)CSC=3N=C(C=C(N3)C)C. References: Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25,61(2):482-491.

Keywords:	PROTAC Sirt2-binding moiety 1
Supplier:	TargetMol
Supplier-Nr:	T18641

Properties

MW:	424.54 D
Formula:	C21H20N4O2S2

Database Information

CAS :

1862237-99-7| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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