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SirReal1-O-Propargyl
Item number: Cay45592-1
SirReal1-O-propargyl is an inhibitor of sirtuin 2 (SIRT2, IC50 = 2.4 µM) and a proteolysis-targeting chimera (PROTAC) building block. It is selective for SIRT2 over SIRT1 (IC50 = >100 µM). When conjugated with azido-thalidomide (Cay26146), SirReal1-O-propargyl has been used in the synthesis of a PROTAC that drives...
| Keywords: | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-[[3-(2-propyn-1-yloxy)phenyl]methyl]-2-thiazolyl]-acetamide |
| Application: | SIRT2 inhibitor |
| CAS | 1862237-99-7 |
| MW: | 424.54 D |
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SirReal1-O-propargyl
Item number: TGM-T18641-100mg
Description: SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 µM. It operates by binding to the cereblon ligand through a linker, facilitating the formation of PROTAC for the degradation of Sirt2[1]. Target: Others....
| Keywords: | PROTAC Sirt2-binding moiety 1 |
| CAS | 1862237-99-7 |
| MW: | 424.54 D |
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