Setomimycin

Setomimycin is a pre-anthraquinone originally isolated from S. pseudovenezuelae. It is active against a variety of Gram-positive bacteria, including S. aureus, B. subtilis, B. cereus, and M. smegmatis (MICs = 1.56-3.13 µg/ml). It also reduces tumor growth in a Sarcoma-180 mouse solid tumor model when administered at a dose of 200 mg/kg per day for seven days.Formal Name: 1,1'-diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl-[9,9'-bianthracene]-4,4'(1H,1'H)-dione. CAS Number: 69431-87-4. Synonyms: Antibiotic A 39183B. Molecular Formula: C34H28O9. Formula Weight: 580.6. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, DMSO: soluble. SMILES: CC(C(C(C)=O)C1=C(C2=C3C(C(CC(C)(O)C3C(C)=O)=O)=C(O)C4=C(O)C=CC=C24)C5=CC=CC(O)=C5C(O)=C16)=CC6=O. InChi Code: InChI=1S/C34H28O9/c1-13-11-20(39)27-29(22(13)14(2)35)25(16-7-5-9-18(37)23(16)32(27)41)26-17-8-6-10-19(38)24(17)33(42)28-21(40)12-34(4,43)31(15(3)36)30(26)28/h5-11,22,31,37-38,41-43H,12H2,1-4H3. InChi Key: BIEJOJJMQZEKED-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces aurantiacus JA 4570.