SEN-177

SEN-177 is a glutaminyl cyclase inhibitor (IC50 = 53 nM). It reduces polyglutamine aggregation in HeLa cells expressing EGFP-HTT-Q74, an in vitro model of Huntington's disease when used at concentrations of 12.5 and 25 µM. SEN-177 (50 µM) reduces polyglutamine aggregation in primary mouse neurons expressing EGFP-Q80.Formal Name: 6'-fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine. CAS Number: 2117405-13-5. Molecular Formula: C18H19FN6. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: FC1=NC=C(C2=C(N3CCC(CC3)C4=NN=CN4C)N=CC=C2)C=C1. InChi Code: InChI=1S/C18H19FN6/c1-24-12-22-23-17(24)13-6-9-25(10-7-13)18-15(3-2-8-20-18)14-4-5-16(19)21-11-14/h2-5,8,11-13H,6-7,9-10H2,1H3. InChi Key: AJIAMIPUWJQSPR-UHFFFAOYSA-N.