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Item number: Cay40449-25

SEN-177 is a glutaminyl cyclase inhibitor (IC50 = 53 nM). It reduces polyglutamine aggregation in HeLa cells expressing EGFP-HTT-Q74, an in vitro model of Huntington's disease when used at concentrations of 12.5 and 25 µM. SEN-177 (50 µM) reduces polyglutamine aggregation in primary mouse neurons expressing...

Keywords:	6'-fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine
Application:	Glutaminyl cyclase inhibitor
CAS	2117405-13-5
MW:	338.4 D

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