SC-560

SC-560
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70340-1 1 mg -

6 - 10 business days*

18.00€
Cay70340-5 5 mg -

6 - 10 business days*

79.00€
Cay70340-10 10 mg -

6 - 10 business days*

140.00€
Cay70340-25 25 mg -

6 - 10 business days*

307.00€
 
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which... more
Product information "SC-560"
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 µM. Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated. Formal Name: 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole. CAS Number: 188817-13-2. Molecular Formula: C17H12ClF3N2O. Formula Weight: 352.7. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 150 mg/ml, DMF:PBS (1:1): 1.2 mg/ml, DMSO: 24 mg/ml, Ethanol: 22 mg/ml. lambdamax: 232, 251 nm. SMILES: COc1ccc(cc1)n1nc(cc1c1ccc(Cl)cc1)C(F)(F)F. InChi Code: InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3. InChi Key: PQUGCKBLVKJMNT-UHFFFAOYSA-N.
Keywords: 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Supplier: Cayman Chemical
Supplier-Nr: 70340

Properties

Application: COX-1 inhibitor
MW: 352.7 D
Formula: C17H12ClF3N2O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 188817-13-2| Find alternatives
KEGG ID : K00509 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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