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SB-4 is an activator of bone morphogenetic protein 4 (BMP4) signaling. It induces BMP4 signaling in a reporter assay using HEK293 cells expressing a recombinant human BMP4 response element (EC50 = 74 nM). SB-4 (10 µM) increases phosphorylation of SMAD1, -5, and -9 in HEK293 cells. It also induces Blimp1 and Tfap2c expression, markers of germline differentiation, in mouse embryonic stem cells.Formal Name: 2-[[(4-bromophenyl)methyl]thio]-benzoxazole. CAS Number: 100874-08-6. Molecular Formula: C14H10BrNOS. Formula Weight: 320.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: BrC1=CC=C(CSC2=NC3=C(O2)C=CC=C3)C=C1. InChi Code: InChI=1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2. InChi Key: JDVOIBFEFVKUPL-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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