SB-3CT

SB-3CT is a selective, mechanism-based inhibitor of the gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9 (Kis = 28 and 400 nM, respectively). First pass metabolism of SB-3CT in vivo produces a monohydroxylated metabolite that has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively). Both SB-3CT and its active metabolite can cross the blood-brain barrier and have utility in diseases of the central nervous system, such as stroke and traumatic brain injury. SB-3CT may have applications in other pathologies involving gelatinases, including cancer, cardiovascular diseases, and inflammation.Formal Name: 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane. CAS Number: 292605-14-2. Synonyms: Matrix Metalloproteinase-2/9 Inhibitor IV, MMP-2/MMP-9 Inhibitor IV. Molecular Formula: C15H14O3S2. Formula Weight: 306.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 15 mg/ml, Ethanol: 2 mg/ml. lambdamax: 244 nm. SMILES: O=S(C(C=C1)=CC=C1OC2=CC=CC=C2)(CC3SC3)=O. InChi Code: InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2. InChi Key: LSONWRHLFZYHIN-UHFFFAOYSA-N.