SB-207266

The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.{34073, 34070} In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production. In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis.{34073, 34072, 34071} In a dog model, SB-207266 (0.1-100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg. SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure.Formal Name: N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide. CAS Number: 152811-62-6. Synonyms: Piboserod. Molecular Formula: C22H31N3O2. Formula Weight: 369.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 20 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH7.2)(1:20): 0.05 mg/mL. lambdamax: 224, 263, 294 nm. SMILES: CCCCN1CCC(CNC(C2=C3N(CCCO3)C4=C2C=CC=C4)=O)CC1. InChi Code: InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26). InChi Key: KVCSJPATKXABRQ-UHFFFAOYSA-N.