Salmeterol-d3

Salmeterol-d3 is intended for use as an internal standard for the quantification of salmeterol (Cay-16009) by GC- or LC-MS. Salmeterol is a long-acting beta2-adrenergic receptor agonist (beta2-AR, EC50s = 0.79, 63.1, and 9.4 nM for beta2-, beta1-, and beta3-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM. Salmeterol binds to an exosite domain of beta2-adrenergic receptors, producing a slow onset of action and prolonged activation. Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.Formal Name: 6-hydroxy-alpha3-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethan-alpha1,alpha1,alpha3-d3-ol. CAS Number: 497063-94-2. Molecular Formula: C25H34D3NO4. Formula Weight: 418.6. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 50 mM. SMILES: OC([2H])([2H])C1=CC(C(O)([2H])CNCCCCCCOCCCCC2=CC=CC=C2)=CC=C1O. InChi Code: InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2/i20D2,25D. InChi Key: GIIZNNXWQWCKIB-LPUTUNIKSA-N.