202 products were found matching "K04142"!

For- flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Olodaterol is a selective agonist of beta2-adrenergic receptors (beta2-ARs, EC50s = 97.7 and 2,725 nM for human beta2- and beta1-ARs, respectively). In vivo, olodaterol completely reverses acetylcholine-induced bronchoconstriction without cardiovascular side effects in guinea pigs. It also exhibits dose-dependent...

Salbutamol-d3 is intended for use as an internal standard for the quantification of salbutamol by GC- or LC-MS. Salbutamol is an agonist of the beta2-adrenergic receptor (beta2-AR). It induces bronchodilation in isolated guinea pig trachea rings (EC50 = 19 nM). Salbutamol selectively binds to the beta2-AR over the...

Formoterol is a selective agonist of the beta2-adrenergic receptor (beta2-AR, Kis = 7.58 and 2,630 nM for beta2- and beta1-ARs, respectively). It is selective for beta-ARs in isolated guinea pig trachea over those in atrial tissue (pD2s = 9.29 and 6.98, respectively) and has a long duration of action. Aerosolized...

ICI 118551 is a potent, selective antagonist of the beta2-adrenergic receptor (Ki = 0.7 nM for the beta2 receptor, compared with 49.5 and 611 nM for beta1 and beta3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.Formal Name:...

Indacaterol is a long-acting and selective beta2-adrenergic receptor (beta2-AR) agonist (EC50 = 8.71 nM for increasing intracellular cAMP levels in vitro). It is selective for beta2-ARs over beta1- and beta3-ARs (Kis = 43.6, 616.6, and 3,311.3 nM, respectively). Indacaterol inhibits bronchoconstriction induced by...

(±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for alpha1A-, beta2-, and beta1-adrenergic receptors, respectively). Through these receptors, (±)-epinephrine may induce either contraction or relaxation of vascular smooth...

Salmeterol is a long-acting beta2-adrenergic receptor agonist (beta2-AR, EC50s = 0.79, 63.1, and 9.4 nM for beta2-, beta1-, and beta3-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via...

Clenbuterol is an agonist of beta2-adrenergic receptors (beta2-ARs). It induces relaxation of equine tracheal muscle strips (EC50 = 2.1 nM). Clenbuterol (300 nM) increases the number of autophagosomes and autophagic flux in HepG2 cells. It increases blood flow to adipose tissue and induces weight gain in rats when...

Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in...

Salbutamol is an agonist of the beta2-adrenergic receptor (beta2-AR, Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for beta2-ARs over beta1- and beta3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 µg/kg, i.v.) reduces acetylcholine-induced...