Salbutamol (hydrochloride)

Salbutamol is an agonist of the beta2-adrenergic receptor (beta2-AR, Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for beta2-ARs over beta1- and beta3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 µg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).Formal Name: alpha1R-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol, monohydrochloride. CAS Number: 50293-90-8. Synonyms: Levalbuterol, (-)-Salbutamol, (R)-Salbutamol. Molecular Formula: C13H21NO3 . HCl. Formula Weight: 275.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 12 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 228, 276 nm. SMILES: OCC1=C(O)C=CC([C@@H](O)CNC(C)(C)C)=C1.Cl. InChi Code: InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15,/h4-6,12,14-17H,7-8H2,1-3H3,1H/t12-,/m0./s1. InChi Key: OWNWYCOLFIFTLK-YDALLXLXSA-N.