Saikosaponin F

Saikosaponin F is a triterpenoid saponin that has been found in B. chinensis and an antagonist of transient receptor potential ankyrin 1 (TRPA1). It inhibits calcium flux induced by polygodial (Cay-14979) or AITC in HEK293 cells expressing human TRPA1 when used at concentrations ranging from 0.5 to 1.5 µM.Formal Name: (3beta,16beta)-16,28-dihydroxyolean-12-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-[beta-D-glucopyranosyl-(1->6)]-beta-D-glucopyranoside. CAS Number: 62687-63-2. Molecular Formula: C48H80O17. Formula Weight: 929.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. SMILES: C[C@@]12C([C@@]3([H])[C@@]([C@H](C2)O)(CCC(C)(C3)C)CO)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)CO[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C)C. InChi Code: InChI=1S/C48H80O17/c1-22-31(52)33(54)37(58)41(61-22)65-39-26(20-60-40-36(57)34(55)32(53)25(19-49)62-40)63-42(38(59)35(39)56)64-30-12-13-45(6)27(44(30,4)5)11-14-46(7)28(45)10-9-23-24-17-43(2,3)15-16-48(24,21-50)29(51)18-47(23,46)8/h9,22,24-42,49-59H,10-21H2,1-8H3/t22-,24-,25+,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38+,39+,40+,41-,42-,45-,46+,47+,48+/m0/s1. InChi Key: SXILFEBNQCRWAL-VERCZQKXSA-N. Origin: Plant/Bupleurum scorzonerifolium root.