Rubratoxin A

Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A, IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.Formal Name: (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione. CAS Number: 22467-31-8. Synonyms: BRN 1633008, HSDB 3532. Molecular Formula: C26H32O11. Formula Weight: 520.5. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: Acetonitrile: soluble, DMSO: soluble. SMILES: O=C1C2=C(C[C@@]([C@H](O)[C@]3([H])CC=CC(O3)=O)([H])CC(C(OC4=O)=O)=C4[C@H](O)[C@]2([H])[C@H](O)CCCCCC)C(O)O1. InChi Code: InChI=1S/C26H32O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-23,27,29-31H,2-5,7-8,10-11H2,1H3/t12-,15+,16-,20+,21-,22-,23?/m0/s1. InChi Key: XOEFANNJIKAWGX-RRIJHKHGSA-N. Origin: Fungus/Penicillium sp..