107 products were found matching "K04382"!

Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also...

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does...

LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity. It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 µM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells....

Sodium salt form of okadaic acid, with somewhat greater stability after it is put into organic solvents.

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 µM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases...

Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2 classes, in numerous cell types. Non-phorbol type tumor promoter.

Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A, IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells...

Okadaic acid is a non-phorbol type tumor promoter. Potent inhibitor of protein phosphatases in numerous cell types.

Isolated from Penicillium sp. Soluble in methanol, ethanol, acetone or DMSO. Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic.

Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Cay-14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively). It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a...

Description: LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor. Target: Phosphatase. Smiles: C(=O)(C1[C@]2(O[C@@](C1C(O)=O)(CC2)[H])[H])N3CCN(C)CC3. References: Bai X, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via...