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Okadaic Acid
Okadaic Acid

Item number: Cay10011490-25

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does...
Keywords: 35-demethyl DTX1, Acanthifolicin, NSC 677083, OA,...
Application: PP1 PP2A PP3 inhibitor
CAS 78111-17-8
MW: 805 D
From 57.00€ *
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Calyculin A
Calyculin A

Item number: Cay19246-10

Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively). It is without significant effect against PP2B, PP2C, and PP4. Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit...
Keywords: (-)-Calyculin A,...
Application: Cell-permeable PP1 / PP2A inhibitor
CAS 101932-71-2
MW: 1009.2 D
From 124.00€ *
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Protein Phosphatase 2A C subunit (human recombinant, L309 deletion)
Protein Phosphatase 2A C subunit (human recombinant, L309...

Item number: Cay10011237-10

Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also...
Keywords: RP-C, PPP2CA, PP2A-alpha, EC=3.1.3.16, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit...
Application: Enzyme activity
MW: 38,6 kD
294.00€ *
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Okadaic acid, sodium salt
Okadaic acid, sodium salt

Item number: LKT-O4104.25

Sodium salt form of okadaic acid, with somewhat greater stability after it is put into organic solvents.
Application: Phosphatase inhibitor
CAS 209266-80-8
MW: 827 D
From 218.00€ *
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Cantharidin
Cantharidin

Item number: LKT-C0255.25

CAS 56-25-7
MW: 196,2 D
From 106.00€ *
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PP2A-alpha, His-tag/PP2AR, GST-tag
PP2A-alpha, His-tag/PP2AR, GST-tag

Item number: BPS-30056

Protein complex of human protein phosphatase 2A catalytic subunit (PP2Aalpha) also known as TPD3, RP-C, PP2Ac, and PPP2CA (GenBank Accession NM_002715, a.a. 2-309 with C-terminal His-tag) and human protein phosphatase 2A regulatory subunit (PP2AR) (GenBank Accession NM_014225, a.a. 2-589 with N-terminal GST-tag)....
Keywords: RP-C, PPP2CA, PP2A-alpha, EC=3.1.3.16, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit...
Application: Enzyme kinetics, Inhibitor screening
Reactivity: Human
MW: 36 / 92 kD
506.00€ *
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Norcantharidin
Norcantharidin

Item number: Cay28457-5

Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Cay-14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively). It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a...
Keywords: Demethylcantharidin, NCTD, NSC 59023, (3aR,4S,7R,7aS)-rel-hexahydro-4,7-epoxyisobenzofuran-1,3-dione
Application: PP1 / PP2A inhibitor
CAS 29745-04-8
MW: 168.1 D
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Fostriecin (sodium salt)
Fostriecin (sodium salt)

Item number: Cay14749-100

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 µM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases...
Keywords: Antibiotic CI-920, Phosphotrienin,...
Application: PP2A/PP4 inhibitor
CAS 87860-39-7
MW: 452.4 D
From 374.00€ *
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Okadaic acid
Okadaic acid

Item number: LKT-O4101.1

Okadaic acid is a non-phorbol type tumor promoter. Potent inhibitor of protein phosphatases in numerous cell types.
Keywords: Halochondrine A
Application: Phosphatase inhibitor
CAS 78111-17-8
MW: 805 D
From 343.00€ *
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Rubratoxin A
Rubratoxin A

Item number: AG-CN2-0092-C250

Isolated from Penicillium sp. Soluble in methanol, ethanol, acetone or DMSO. Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic.
Keywords: BRN 1633008, HSDB 3532
Application: PP2A inhibitor
CAS 22467-31-8
MW: 520,2 D
From 330.00€ *
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Calyculin A (CAS 101932-71-2), >98%
Calyculin A (CAS 101932-71-2), >98%

Item number: LC-C-3987_50ug

Soluble in DMSO and ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-10 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Special Hazard: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be...
Keywords: (-)-Calyculin A,...
Application: Cell-permeable PP1 / PP2A inhibitor
CAS 101932-71-2
MW: 1009.17 D
From 104.00€ *
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Okadaic Acid, Sodium Salt (Halochondrine A, Sodium Salt, CAS 209266-80-8), >98%
Okadaic Acid, Sodium Salt (Halochondrine A, Sodium Salt,...

Item number: LC-O-5857_1mg

Solubility: Soluble in DMSO or ethanol. The salt form of okadaic acid has somewhat greater stability than the free acid when stored in organic solvents. Special Hazard: TUMOR PROMOTER - Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure....
Keywords: Halochondrine A
Application: Ser/Thr phosphatase inhibitor
CAS 209266-80-8
MW: 826,98 D
From 82.00€ *
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