Rofecoxib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2),... more
Product information "Rofecoxib"
Description: Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Target: COX. Smiles: O=C1C(=C(CO1)C2=CC=C(S(C)(=O)=O)C=C2)C3=CC=CC=C3. References: Chan CC, et al. J Pharmacol Exp Ther. 1999, 290(2), 551-560.
| Keywords: | MK 966, MK-0966 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1185 |
Properties
| Application: | Targets prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1] (PTGS2, COX2) |
| MW: | 314.36 D |
| Formula: | C17H14O4S |
Database Information
| CAS : | 162011-90-7| Matching products |
| KEGG ID : | K11987 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P330, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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