Ro 60-0175

Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = >1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, alpha1-, alpha2-, and beta1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and µ-, delta-, and kappa-opioid receptors (IC50s = >1,000 nM), but does bind to beta2-adrenergic receptors (IC50 = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 (Cay-10096) or the 5-HT2A antagonist MDL 100,907 (volinanserin, Cay-15936).Formal Name: (alphaS)-6-chloro-5-fluoro-alpha-methyl-1H-indole-1-ethanamine, (2E)-2-butenedioate. CAS Number: 169675-09-6. Molecular Formula: C11H12ClFN2 . C4H4O4. Formula Weight: 342.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 223, 280 nm. SMILES: N[C@@H](C)CN1C=CC2=CC(F)=C(Cl)C=C21.OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/C11H12ClFN2.C4H4O4/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15,5-3(6)1-2-4(7)8/h2-5,7H,6,14H2,1H3,1-2H,(H,5,6)(H,7,8)/b,2-1+/t7-,/m0./s1. InChi Key: CEPHEXXZGQBXGT-XZTIXWOLSA-N.