Ro 46-2005
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An ETA and ETB antagonist (IC50s = 220 and 160 nM, respectively), inhibits endothelin-1-induced... more
Product information "Ro 46-2005"
An ETA and ETB antagonist (IC50s = 220 and 160 nM, respectively), inhibits endothelin-1-induced secretion of arachidonic acid in primary rat mesangial cells (IC50 = 1.8 µM), prevents sarafotoxin S6-induced relaxation in preconstricted rat mesenteric arteries (pA2 = 6.47), increases cerebral blood flow in a rat model of subarachnoid hemorrhage at 3 mg/kg, decreases systolic blood pressure in sodium-depleted monkeys at 30 or 100 mg/kg
| Keywords: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-benzenesulfonamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43523 |
Properties
| Application: | Endothelin receptor type A/B antagonist |
| MW: | 473.54 D |
| Formula: | C23H27N3O6S |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 150725-87-4| Matching products |
| KEGG ID : | K04198 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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