Ro 20-1724

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 µM). It weakly inhibits PDE3 with a Ki value greater than 25 µM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.Formal Name: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone. CAS Number: 29925-17-5. Synonyms: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone. Molecular Formula: C15H22N2O3. Formula Weight: 278.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 230, 280 nm. SMILES: COC1=C(OCCCC)C=C(CC2CNC(N2)=O)C=C1. InChi Code: InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18). InChi Key: PDMUULPVBYQBBK-UHFFFAOYSA-N.