Ro 08-2750

Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTR in PC12 cells when used at a concentration of 100 µM. It also binds to NGF dimers (Kd = ~1 µM) to induce a conformational change that prevents NGF binding to p75NTR or tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in beta-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.Formal Name: 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde. CAS Number: 37854-59-4. Molecular Formula: C13H10N4O3. Formula Weight: 270.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 248, 288, 335, 460 nm. SMILES: CC1=C(C=O)C=C2C(N=C(C(N3)=O)C(N2C)=NC3=O)=C1. InChi Code: InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20). InChi Key: JDEMVNYMYPJJIM-UHFFFAOYSA-N.