Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay19450-500 | 500 µg | - |
6 - 10 business days* |
324.00€
|
|||
Cay19450-2.5 | 2500 µg | - |
6 - 10 business days* |
1,537.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular... more
Product information "RK-682 (calcium salt)"
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 µM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 µM), an endo-beta-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid.Formal Name: (5R)-4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone, calcium salt (2:1). CAS Number: 332131-32-5. Synonyms: CI-010, TAN 1364B. Molecular Formula: [C21H35O5]2 . Ca. Formula Weight: 775.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1C(C(CCCCCCCCCCCCCCC)=O)=C([O-])[C@@H](CO)O1.O=C2C(C(CCCCCCCCCCCCCCC)=O)=C([O-])[C@@H](CO)O2.[Ca+2]. InChi Code: InChI=1S/3C21H36O5.Ca/c3*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25,/h3*18,22,24H,2-16H2,1H3,/q,,,+2/p-3/t3*18-,/m111./s1. InChi Key: YVSMJCYMLTVSLF-AFZPLCFTSA-K. Origin: Bacterium/Streptomyces sp..
Keywords: | CI-010, TAN 1364B, (5R)-4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone, calcium salt (2:1) |
Supplier: | Cayman Chemical |
Supplier-Nr: | 19450 |
Properties
Application: | Protein tyrosine phosphatase inhibitor |
MW: | 775.1 D |
Formula: | [C21H35O5]2 . Ca |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 332131-32-5| Matching products |
KEGG ID : | K05696 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed