93 products were found matching "K05696"!

Description: PTP1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli. The accession number is P18031.

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK, inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the...

KY-266 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B, IC50 = 0. µM). It enhances insulin-induced phosphorylation of insulin receptors in HepG2 cells when used at concentrations of 1, 3, and 10 µM. In vivo, KY-266 (10 and 30 mg/kg) reduces plasma glucose and triglyceride levels and hemoglobin A1c (HbA1c)...

Protein tyrosine phosphatase (PTPs) are an enzyme superfamily that includes about 100 human proteins. Their function is to remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is of paramount...

Active protein tyrosine phosphatase, full length, (a.a. 1-436), (Gene bank accession number M31724) with N terminal GST tag, MW=76 kDa, expressed in an E. coli expression system.

3,8'-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B, IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM. 3,8'-Biapigenin...

Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin. Bakuchiol also inhibits DNA polymerase and...

Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the...

Protein phosphorylation is one of the most important post-translational modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of insulin receptor kinases and plays a critical role in insulin...

Active protein tyrosine phosphatase, recombinant from E.coli, catalytic domain, (a.a. 1-321), (Gene bank accession no. M31724) with N-terminal GST tag, MW=63.3 kDa, expressed in an E. coli expression system.

Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation,...

Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation,...