Rivanicline (hydrochloride)

An a4ß2 subunit-containing nAChR agonist, selectively induces rubidium ion efflux in M10 cells expressing a4ß2 subunit-containing nAChRs (EC50 = 0.73 µM for the chicken channels) over M10 cells expressing a3ß4- or a1ß1?d subunit-containing receptors (EC50s = >1,000 nM for both for the chicken channels) and a panel of 34 receptors, ion channels, and kinases at 10 µM, induces contractions in isolated guinea pig ileum (EC30 = 15 µM), prevents scopolamine-induced memory deficits in the passive avoidance test in mice at 0.6 µmol/kg, decreases the number of errors in the radial arm maze in a rat model of ibotenic acid-induced memory impairment at 0.3, 0.6 or 1.2 µmol/kg. Formulation: A solid. InChI: InChI=1S/C10H14N2.ClH/c1-11-7-3-2-5-10-6-4-8-12-9-10,/h2,4-6,8-9,11H,3,7H2,1H3,1H/b5-2+,. InChIKey: HGCYAFBPAWHPTH-DPZBITMOSA-N. SMILES: CNCC/C=C/C1=CN=CC=C1.Cl