Rilmenidine-d4

Rilmenidine-d4 is intended for use as an internal standard for the quantification of rilmenidine (Cay-16988) by GC- or LC-MS. Rilmenidine is an antihypertensive agent. It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as alpha2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg. Rilmenidine (1 µM) increases levels of LC3-II, a marker of autophagy, in PC12 cells. Formulations containing rilmenidine have been used in the treatment of hypertension.Formal Name: N-(dicyclopropylmethyl)-4,5-dihydro-4,5-d2-2-oxazol-4,5-d2-amine. CAS Number: 85047-14-9. Synonyms: Oxaminozoline-d4. Molecular Formula: C10H12D4N2O. Formula Weight: 184.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: [2H]C(C([2H])([2H])O1)([2H])N=C1NC(C2CC2)C3CC3. InChi Code: InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)/i5D2,6D2. InChi Key: CQXADFVORZEARL-NZLXMSDQSA-N.