RG3039

RG3039 is an inhibitor of mRNA decapping scavenger enzyme (DcpS, IC50 = 0.069 nM). It prevents denervation of the neuromuscular junction (NMJ) and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of spinal muscular atrophy (SMA) induced by knockout of the gene encoding survival motor neuron 1 (Smn1) when administered at a dose of 10 mg/kg. RG3039 improves survival and motor function in the same model.Formal Name: 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-2,4-quinazolinediamine. CAS Number: 1005504-62-0. Molecular Formula: C21H23Cl2N5O. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 222, 244 nm. SMILES: ClC1=CC=CC(Cl)=C1CN2CCC(CC2)COC3=C4C(N)=NC(N)=NC4=CC=C3. InChi Code: InChI=1S/C21H23Cl2N5O/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17/h1-6,13H,7-12H2,(H4,24,25,26,27). InChi Key: MNLHFGXIUJNDAF-UHFFFAOYSA-N.