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Item number: Cay36589-1

RG3039 is an inhibitor of mRNA decapping scavenger enzyme (DcpS, IC50 = 0.069 nM). It prevents denervation of the neuromuscular junction (NMJ) and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of spinal muscular atrophy (SMA) induced by knockout of the gene...

Keywords:	5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-2,4-quinazolinediamine
Application:	DcpS (m7GpppX diphosphatase) inhibitor
CAS	1005504-62-0
MW:	432.4 D

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Rg3039

Item number: TGM-T3336-100mg

Description: Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039...

Keywords:	PF-06687859
Application:	DcpS (m7GpppX diphosphatase) inhibitor
CAS	1005504-62-0
MW:	432.35 D

From 31.00€ *

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