RG-14620

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. RG-14620 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 3 µM in HT-22 cells.Formal Name: alpha-[(3,5-dichlorophenyl)methylene]-3-pyridineacetonitrile. CAS Number: 136831-49-7. Molecular Formula: C14H8Cl2N2. Formula Weight: 275.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 206, 309 nm. SMILES: ClC1=CC(/C=C(C#N)/C2=CN=CC=C2)=CC(Cl)=C1. InChi Code: InChI=1S/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4+. InChi Key: TYXIVBJQPBWBHO-UUILKARUSA-N.