Regorafenib N-oxide

Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Cay-18498). It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft models when administered at a dose of 1 mg/kg.Formal Name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-oxide. CAS Number: 835621-11-9. Molecular Formula: C21H15ClF4N4O4. Formula Weight: 498.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 264 nm. SMILES: O=C(NC1=C(F)C=C(OC2=CC=[N](C(C(NC)=O)=C2)=O)C=C1)NC3=CC(C(F)(F)F)=C(Cl)C=C3. InChi Code: InChI=1S/C21H15ClF4N4O4/c1-27-19(31)18-10-13(6-7-30(18)33)34-12-3-5-17(16(23)9-12)29-20(32)28-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,28,29,32). InChi Key: NUCXNEKIESREQY-UHFFFAOYSA-N.