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Regorafenib N-oxide
Item number: Cay35101-1
Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Cay-18498). It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft...
| Keywords: | 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-oxide |
| Application: | Regorafenib active metabolite |
| CAS | 835621-11-9 |
| MW: | 498.8 D |
From 49.00€
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Regorafénib N-oxyde (M2)
Item number: TGM-T10157-100mg
Description: Regorafénib N-oxyde M2 is an active metabolite of Regorafenib, a multi-target inhibitor for VEGFR1/2/3, PDGFRbeta, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM). Target: VEGFR, c-Kit, PDGFR, Drug Metabolite, c-RET, Raf. Smiles:...
| CAS | 835621-11-9 |
| MW: | 498.81 D |
From 36.00€
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