RBPJ Inhibitor-1

RBPJ inhibitor-1 is an inhibitor of recombination signal binding protein for immunoglobulin kappa J region (RBPJ, IC50 = 0.18 µM in a reporter assay). It also inhibits the protein-protein interaction between RBPJ and the neurogenic locus notch homolog protein 2 (Notch2) intracellular domain (NICD) and the protein-protein interaction between RBPJ and small histidine-alanine-rich protein (SHARP) in cell-free assays. RBPJ inhibitor-1 (15 µM) induces cell cycle arrest at the G2/M phase and apoptosis in UT-SCC-42B squamous cell carcinoma cells. It reduces tumor volume in D. rerio larvae injected with UT-SCC-42B cells when administered in the tank water at a concentration of 5 µM. SMILES O=C(N)C1=C(C=C(C2=CC=NN2C)C=C1)OC3=C(C=CC=C3)F InChi Code InChI=1S/C17H14FN3O2/c1-21-14(8-9-20-21)11-6-7-12(17(19)22)16(10-11)23-15-5-3-2-4-13(15)18/h2-10H,1H3,(H2,19,22) InChi Key MFSSHRCJKRDIOL-UHFFFAOYSA-N